Graft-versus-leukaemia immunity is retained following treatment with post-transplant cyclophosphamide alone or combined with tocilizumab in humanised mice.

At endpoint, the difference between all groups approached significance ( P = 0.09), with the clinical score of D1 and D3 mice significantly higher than that of Ctrl mice ( P = 0.02 and P = 0.03, respectively).

also in 8,237 other papers

While this increase did not reach statistical significance in the livers of mice, it did reach statistical significance in the spleen (Supplementary figure 3 ), indicating that PTCy may promote hTh17 differentiation, or Treg/Th17 plasticity in this model.

also in 111,027 other papers