Radiation therapy for retroperitoneal sarcoma: practice patterns in North America.

However, post-hoc analyses demonstrated (1) a significant improvement in true local recurrence rates with pre-operative RT; (2) a potential loss of statistical power to detect abdominal recurrence free survival (ARFS) benefit due to poor RT protocol compliance; (3) a near-significant trend towards ARFS benefit for patients with well-differentiated liposarcomas and other low-grade histologies, a trend which achieved statistical significance on inclusion of an expansion cohort [ 11 – 13 ].

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Our own study identified a trend ( p = 0.07) towards improved overall survival among patients receiving pre-operative RT, but this did not reach statistical significance.

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