Advanced brain aging in Parkinson's disease with cognitive impairment.

NPJ Parkinsons Dis · 2024 · PMC10944471 · PMID 38493188

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.1140

boldest claim

The sentences

a statistical trendP = 0.080so close (0.05 < p ≤ 0.1)

The disease severity, as assessed using the total UPDRS score, also revealed a statistical trend with the increased GM-PAD (β = 0.166, adjusted P = 0.080).

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showed a trendP = 0.092so close (0.05 < p ≤ 0.1)

The symptom related to experiences of daily living (assessed using the UPDRS part II) was significantly associated with the increased GM-PAD (β = 0.440, adjusted P = 0.036) and showed a trend with the increased WM-PAD (β = 0.416, adjusted P = 0.092).

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did not reach statistical significanceP = 0.114not close (p > 0.1)

The results showed that the GM-PAD was significantly greater in PD-CI compared to PD-NCI (adjusted P = 0.027) while the difference in WM-PAD did not reach statistical significance (adjusted P = 0.114) (Supplementary Note 1 ).

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