Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.

Elife · 2024 · PMC10945611 · PMID 38285009

Europe PMC DOI

hedged sentences

0.0726

closest p · 1.5× alpha

0.0726

boldest claim

The sentences

did not reach statistical significancep=0.0726so close (0.05 < p ≤ 0.1)

Although this reduction did not reach statistical significance using a Kruskal-Wallis with Dunn’s test (p=0.0726), it was statistically significant using a t-test (p=0.0384).

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showed a trendp = 0.0726so close (0.05 < p ≤ 0.1)

Kruskal-Wallis with Dunn’s test showed a trend to a reduced levels of DKK3 in the extracellular fraction when we compared neurons treated with Aβo and APV with those neurons treated with Aβ and vehicle (p = 0.0726).

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