METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma.

Although METTL3 showed a trend of subtelomere-specific decrease in TERRA expression from some chromosome ends, the overall difference in TERRA levels between METTL3-KD and control cells was not statistically significant ( Supplementary Figure S2B, C ).

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In a smaller cohort of ALT+ NBs ( n = 21), we observed that higher expression of METTL3 and METTL14 was significantly correlated with worse EFS, while hnRNPA2B1 showed a trend towards worse EFS, although it did not reach statistical significance (Figure 6M ; Supplementary Figure S6I ).

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