Barely Significant
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Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety.

Transl Psychiatry · 2024 · PMC10954635 · PMID 38509093

Europe PMCDOI
3
hedged sentences
0.0007
closest p · 0.0× alpha
0.0940
boldest claim

The sentences

highly significantp = 0.0007actually significant
5 , compared to the vehicle-control group, AAV9-CRISPR/Cas9-treated mice showed a highly significant increase in the number of spontaneous alterations ( p = 0.0007).

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did not reach statistical significancep = 0.094so close (0.05 < p ≤ 0.1)
Although there was a 24% decrease in mRNA expression between scrambled- and shRNA-treated neurons, this finding did not reach statistical significance ( p = 0.094).

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a strong trendno p-value reported
In addition, while the increase in the number of interactions with object A during the acquisition period was not significant, there does appear to be a strong trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.