Additionally, milrinone (MD [95% CrI] = 0.43 [−0.84, 1.7]) showed a trend of increasing Lac levels, but this trend was not statistically significant due to the wide width of the 95% CrI, which included the null value.
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Efficacy and safety of levosimendan in patients with sepsis: a systematic review and network meta-analysis.
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However, the observed differences did not reach statistical significance as levosimendan at 0.075 μg/kg/min was only reported in two studies, and there was heterogeneity within these studies. 4 Discussion The results of this network meta-analysis showed that levosimendan significantly improved CI levels and Lac levels in patients with sepsis.