Antiretroviral drugs from multiple classes induce loss of excitatory synapses between hippocampal neurons in culture.

Front Pharmacol · 2024 · PMC10963620 · PMID 38533258

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a strong trendp = 0.06so close (0.05 < p ≤ 0.1)

While 8-OH EFV in the presence of Nim did not induce a significant decrease in PSDs relative to the vehicle control, there was a strong trend towards loss ( p = 0.06).

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did not reach statistical significanceno p-value reported

Rilpivirine (RPV) also trended towards loss but the effect did not reach statistical significance.

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