Temporal trend analysis of acute hepatitis B virus infection in China, 1990-2019.

Age–period–cohort analysis The age–period–cohort analysis revealed that after controlling for the effects of period and cohort, the age-specific RR of AHBV infection for both genders showed a trend towards a rapid increase followed by a slow decline with advancing age.

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A nonzero CI indicated a significant trend, while a CI containing zero represented a nonsignificant trend at the 0.05 significance level.

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The annual per cent change (APC) and average APC (AAPC) were estimated using the joinpoint regression model, with an APC greater than zero indicating an increasing trend in the CIR and ASIR of AHBV infections in China, an APC less than zero indicating a decreasing trend, and an APC equal to zero indicating stability.

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The implementation of these policies and measures has resulted in a decreasing trend in the national reporting incidence of HBV infection in China, dropping below 1% in 2019.

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