Bumetanide pretreatment caused a small positive shift in the number of electrodes with decreasing spiking activity, but the difference did not reach statistical significance ( Figure 3 D).
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Heterogeneous subpopulations of GABA<sub>A</sub>R-responding neurons coexist across neuronal network scales and developmental stages in health and disease.
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Saline-treated adult Ts65Dn mice showed a trend toward increased anxiety compared with WT mice in this test (slight decrease in time spent in the center of the arena).