Receiving previous therapies, BRAF mutational status, and the completion of the ipilimumab induction sequence failed to reach statistical significance influencing OS, as seen in Table 3 .
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Combined Anti-PD-1 and Anti-CTLA-4 Treatment in Stage IV Melanoma Patients: A Bicentric Analysis of Real-World Data and a Modern Treatment Scenario Proving Lactate Dehydrogenase's Usefulness.
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The sex of the patient did not influence the OS, with a median survival time of 346 days for females (95% CI: 130–1347) and 302 days for males (95% CI: 113–NA) with a p -value that did not reach statistical significance either on the log-rank test, p -value 0.852, or the multivariate Cox regression analysis, p -value 0.254, HR 95% CI: 1.74 (0.67–4.49), as seen in Table 3 .