Barely Significant
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Prevention of Dental Caries: A Review on the Improvements of Toothpaste Formulations from 1900 to 2023.

Dent J (Basel) · 2024 · PMC10969581 · PMID 38534288

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a clear trendno p-value reported
Nevertheless, for almost all ingredients, a clear trend of increasing product numbers can be observed.

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a significant trendno p-value reported
Since 2008, there has been a significant trend towards an increase in the number of toothpaste products containing hydroxyapatite ( Figure 4 ). 3.4.

also in 6,185 other papers

an overall trendno p-value reported
The author compared the results to data from 1988 and found that there was an overall trend towards toothpastes with lower dentin abrasion values without a significant loss of cleaning power; i.e., toothpastes became more efficient from 1988 to 1995.

also in 3,008 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.