T-Cell Subtypes and Immune Signatures in Cutaneous Immune-Related Adverse Events in Melanoma Patients under Immune Checkpoint Inhibitor Therapy.

This difference was not as substantial for CD3 + CD4 + CCR10 + Th22 cells, although responders showed a trend towards higher numbers of Th22 cells in the peripheral blood during an acute cutAE, maintaining this level during therapy ( Figure 3 E and Supplementary Table S2 ).

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This prospective study, designed as an exploratory study to be followed up by larger studies in the future, compared patients with individual clinical manifestations of cutAEs and provided several significant and near-significant results that warrant follow-up.

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