The DUX4-HIF1α Axis in Murine and Human Muscle Cells: A Link More Complex Than Expected.

To increase the model sensitivity, we also increased the dose of pCIneo-DUX4 up to 20 μg to detect a highly significant (compared to 5 μg) increase in the muscle lesion area (median of 24.7%) ( p < 0.001, ANOVA on ranks followed by Dunn’s post hoc test; Figure 4 C,D and Figure S4C ).

also in 132,142 other papers

In myoblasts, though the change in Hif1a expression did not reach statistical significance, we observed decreased levels of Hif1a target genes Vegfa and Pdk1 in DUX4 -expressing cells ( Figure 3 E) , consistent with the reduced percentage of Hif1α + nuclei presented in Figure 3 C.

also in 111,027 other papers

On the contrary, upon DUX4 expression, both PDK1 and VEGFA mRNA levels showed a trend of increasing through differentiation.

also in 53,322 other papers