Paradoxical cancer cell proliferation after FGFR inhibition through decreased p21 signaling in FGFR1-amplified breast cancer cells.

CD24 exhibited a trend of reduction with FGF2 treatment and an increase with PD186866 across all four cell lines, although some comparisons did not reach statistical significance.

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This approach allowed the estimation of cell counts for each population during treatment, revealing a significant trend of paradoxical decreased cell abundance in CAMA1 and MDA-MB-134 FGFR1 amplified cells, and a significant increase of cell abundance for MCF7 and T47D cells without FGFR1 amplification with rising concentrations of FGF2, both at the 14-day timepoint (Fig. 1 B) and time course throughout the 14-day 3D culture (Fig.

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