Moreover, low-dose irradiation in combination with Plk4 overexpression also showed a clear trend to reduce the colony formation capacity of HSPCs in methylcellulose even further, when compared to doxycycline treatment alone ( Fig. 5I ).
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Whole-genome sequencing (WGS) of tumor cells in mini-bulks (30 cells per tumor) showed a trend toward enhanced karyotypic alterations on the E μ MYC/Plk4 transgenic background, but statistical significance was not reached (fig.