Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas.

J Exp Clin Cancer Res · 2024 · PMC10986120 · PMID 38561856

Europe PMC DOI

hedged sentences

0.0717

closest p · 1.4× alpha

0.1406

boldest claim

The sentences

borderline significancep = 0.0717so close (0.05 < p ≤ 0.1)

The orthotopic GBM model showed that mice inoculated with CSMD1-expressing clones of U-87 cells had increased survival than mice inoculated with Ctrl clones of U-87 cells with borderline significance (Fig. 6 F) ( p = 0.0717).

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did not reach statistical significancep = 0.1406not close (p > 0.1)

However, this finding did not reach statistical significance ( p = 0.1406) (Fig. 6 C and D).

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a clear trendno p-value reported

Moreover, there was a clear trend for the downregulation of CSMD1 in the tumor region of mice injected with RCAS-PDGFB + sh Csmd1 compared to RCAS-PDGFB + shGL2.

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