Stroma-infiltrating T cell spatiotypes define immunotherapy outcomes in adolescent and young adult patients with melanoma.

Nat Commun · 2024 · PMC11002019 · PMID 38589406

Europe PMC DOI

hedged sentences

0.0504

closest p · 1.0× alpha

0.0850

boldest claim

The sentences

near-significantP = 0.0504so close (0.05 < p ≤ 0.1)

When AYA patients were stratified by SIL spatiotype regardless of ICI outcome, the SIL high group showed a trend of longer OS and a near-significant longer PFS ( P = 0.0504) compared to SIL low group (Supplementary Fig. 5f, g ).

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showed a trendP = 0.085so close (0.05 < p ≤ 0.1)

The CD8 + :FOXP3 + T cell ratio in ICI-non-resistant AYA melanomas was similar to the adult groups, while the resistant AYA group showed a trend of lower CD8 + :FOXP3 + cell ratio compared to adult non-resistant melanomas ( P = 0.085) (Supplementary Fig. 2d ).

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