Inhibition of ACOX1 enhances the therapeutic efficacy of obeticholic acid in treating non-alcoholic fatty liver disease and mitigates its lipotoxicity.

Front Pharmacol · 2024 · PMC11003388 · PMID 38595921

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failed to reach statistical significancep > 0.05actually significant

Compared to the control group, high-dose OCA, 10,12-Tricosadiynoic acid combined with middle- or low-dose OCA reduced liver fibrosis, although the fibrosis scores failed to reach statistical significance ( Figures 5E, G ) ( p > 0.05).

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did not reach statistical significanceno p-value reported

The results of Masson trichrome staining revealed more severe liver fibrosis in the FXR −/− mouse group supplemented with WY14643, although the difference in liver fibrosis scores did not reach statistical significance ( Figures 3E, G ).

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