Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions.

4e ), and compared to the co-culture with PDAC tumor cells, the macrophages showed a trend toward enhanced expression of PD-L1 (Fig. 4f ).

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The Siglec-9 ligands on M1 CAFs and T1 CAFs were reduced in response to both O- glycosylation and N- glycosylation inhibitors, although this reduction was modest and did not reach statistical significance (Fig. 3b ).

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