Neuroactive metabolites and bile acids are altered in extremely premature infants with brain injury.

Feces At all three time points, a significant or near-significant enrichment was found in biopterin metabolism (day 7: p = 0.004; day 28: p = 0.055; term: p = 0.010).

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A clear trend between the abundance of the primary bile acids CDCA (p = 0.033, FC-log 2 = 3.3), CA (p = 0.110, FC-log 2 = 1.6), and their taurine conjugates (Tau-CDCA: p = 0.067, FC-log 2 = −3.0; Tau-CA: p = 0.110, FC-log 2 = −3.0) between the experimental groups was observed ( Figure 5 E), although only one was regarded as significant based on their p values.

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