Ribosome Profiling and Mass Spectrometry Reveal Widespread Mitochondrial Translation Defects in a Striatal Cell Model of Huntington Disease.

Consistent with this previous report, we also observed a significant reduction in the Idh3a, Slc25a24, and Pck2 protein levels, while Clpp and Me2 showed a decreasing trend that did not reach statistical significance.

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The complex IV subunit mt-Co1 and the complex V subunit mt-Atp8 showed high RPF and a significant trend toward higher ribosome occupancy in the HD-het and HD-homo cells ( Fig. 5 , B and C ).

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