Body composition analysis showed a trend toward reduced fat mass in the HDAC9 transgenic mice, and quantification of adipose tissue depots confirmed that inguinal subcutaneous fat, in particular, was diminished in the HDAC9 TG mice.
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Transgenic Overexpression of HDAC9 Promotes Adipocyte Hypertrophy, Insulin Resistance and Hepatic Steatosis in Aging Mice.
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The HDAC9 TG mice showed a strong trend toward increased ambulation compared to WT mice, though the differences were not statistically significant ( Figure 2 I,J).