The Efficacy of Carfilzomib Treatment in Bortezomib-Refractory Patients-Real Life Experience in a Tertiary Romanian Hospital.

Although the difference in median PFS did not reach statistical significance ( p = 0.107), probably due to the small sample size, the Kaplan–Meier curves clearly demonstrates a notable separation, suggesting a potential clinical relevance of the observed trend, warranting further exploration and consideration in the context of clinical implications.

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In the high-cytogenetic-risk group, although there was a clear trend favoring group 1, the OS difference was not statistically significant—1068 days for group 1, compared to 693 days in group 2 ( p = 0.246) ( Figure 10 ).

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