Novel JAK Inhibitors to Reduce Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation in a Preclinical Mouse Model.

A low dose (4 mg/kg) of WU8 showed a mild trend towards improved survival and less GvHD compared to the vehicle control ( Figure S1A,B ), although not as much as the high dose (20 mg/kg) of the drug ( Figure 5 A,B).

also in 257 other papers

In addition, mice administered WU8 showed a trend towards higher frequencies of Tregs in the spleens of recipient mice on day 6 after allo-HCT compared to the vehicle control ( Figure 5 C).

also in 53,322 other papers

In addition, the administration of WU5, WU8, and WU10 shows a significant trend towards reduction in GvHD by enhancing Tregs and immune reconstitution while suppressing both recipient- and donor-BM-derived APCs, as well as costimulatory protein CD80, on the BM-derived APCs compared to the vehicle control after allo-HCT.

also in 9,775 other papers