A novel bioinformatic approach reveals cooperation between Cancer/Testis genes in basal-like breast tumors.

Expression of HORMAD1 alone tended to decrease the percentage of MaSC, but this trend failed to reach statistical significance.

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Furthermore, this activation correlated with a better response to anthracyclines (used in standard-of-care chemotherapy regimens), although the trend failed to reach significance (Fig.

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In contrast, the co-expression of HORMAD1 and CT83 induced a highly significant, 4-fold increase of the MaSC compartment (Fig. 6E ).

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In the same tumors, DMRTC2 expression tended to associate with poorer survival, however the trend did not reach statistical significance, maybe because the size of the DMRTC2-negative group was small ( n = 20), in line with the prevalent re-expression of DMRTC2) in Her2-positive tumors (Fig. 2E ).

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