Sex-dependent regulation of mucin gene transcription and airway secretion and mechanics following intra-airway IL-13 in mice with conditional loss of club cell Creb1.

Front Physiol · 2024 · PMC11070562 · PMID 38711951

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

a strong trendp = 0.059so close (0.05 < p ≤ 0.1)

However, interestingly, we found a strong trend for loss of club cell Creb1 to augment the percentage of cells that were granulocytes in female airways ( p = 0.059, Figure 3H ; Table 3 ).

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a weak trendno p-value reported

In this case, we saw a weak trend for loss of club cell Creb1 to increase surface Muc5b protein in female airways in response to IL-13 treatment.

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showed a trendno p-value reported

Despite sex-independent increases in Muc5ac mRNA expression, only male mice showed a trend for increased Muc5ac protein concentrations in the lavage fluid.

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