Endocrine Immune-Related Adverse Events Are Independent Predictors of Survival in Patients with Lung Cancer.

Univariate analysis showed a trend towards increased risk of e-irAEs for women (OR, 1.39; 95% CI, 0.95–2.02; p = 0.09), although it was not statistically significant in multivariate analysis ( p = 0.8).

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Although younger age and female sex have been suggested to increase the risk of e-irAEs [ 17 ], a trend towards higher risk in women was identified in the univariate analysis but did not reach statistical significance in the multivariate setting.

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The impact of corticosteroid therapy for irAEs on ICI efficacy is unclear; the organ system affected, the primary tumor type, as well as the timing and dose of systemic steroid therapy may be significant [ 21 , 22 , 23 , 24 ].

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