Hepatocyte-Specific <i>Fads1</i> Overexpression Attenuates Western Diet-Induced Metabolic Phenotypes in a Rat Model.

AAV8-Fads1 treatment led to a decreasing trend in the energy intake in rats fed with the LFHFr diet compared to AAV8-Blank controls.

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Although fasting blood glucose levels showed a trend toward an increase in both LFHFr and HFHFr-fed rats compared to chow-fed rats, that was blunted by AAV8-Fads1.

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Although LFHFr feeding led to a mild increase in hepatic triglyceride and cholesterol contents, the differences did not reach statistical significance.

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