Does opioid therapy enhance quality of life in patients suffering from chronic non-malignant pain? A systematic review and meta-analysis.

Br J Pain · 2024 · PMC11092930 · PMID 38751560

Europe PMC DOI

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a positive trendno p-value reported

In the vote counting analysis of the 25 studies assessing the MCS scale, ten studies exhibited a positive trend, while nine studies demonstrated a negative result.

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did not reach statistical significancep = .052so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

The subgroup analysis of Osteoarthritis demonstrated a significant worsening of the opioid therapy compared to placebo ( p = .048), while the Low Back Pain subgroup showed a trend towards an advantage in the opioid group, although it did not reach statistical significance ( p = .052).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.