Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.

Of the 35 variants, 14 (40%) reached Bonferroni significance ( P < 1.4 × 10 −3 (0.05/35 variants)) and 6 were nominally significant ( P < 0.05) with concordant directions of effect in MVP (Supplementary Table 10 ).

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units per allele, 95% CI: −0.40 to −0.16, P = 5.8 × 10 −6 ) and numerically lower odds of cirrhosis, although the latter association did not reach statistical significance (OR: 0.36, 95% CI: 0.05–2.42, P = 0.296; Supplementary Table 23 ).

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