Chemogenetic inhibition of the lateral hypothalamus effectively reduces food intake in rats in a translational proof-of-concept study.

We would like to note that despite the absence of significant effects in the AAV5 group, there appears to be a non-significant, but strong tendency to reach an early effect at the 30- and 60-min time points, where both ANOVA and post-hoc tests yielded near-significant results (Fig. 3 E; ANOVA 30 min: F 3,12 = 3.102, p = 0.067; Post-hoc Tukey HSD test DCZ 100 μg/kg vs.

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2 B), while in the case of the AAV9 serotype, the effects of CNO did not reach statistical significance (Fig. 2 C).

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This effect was sustained and remained highly significant throughout the whole 8h post-re-feeding period.

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