Altered Expression of PDE4 Genes in Schizophrenia: Insights from a Brain and Blood Sample Meta-Analysis and iPSC-Derived Neurons.

PDE4B was found to be overexpressed in the affected twins, although this was marginally significant ( Figure 5 F, control vs. schizophrenia, p = 0.087; control vs. co-twin p = 0.16).

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At the same time, the PDE4A gene showed a trend toward overexpression (controls vs.

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We conclude that beyond the significant downregulation of a specific gene, PDE4B, we see a significant trend toward downregulation of the four PDE4 genes as a group.

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