Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.

Elife · 2024 · PMC11126309 · PMID 38787369

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantp=4.0e-5actually significant

A-levels education and no education both showed highly significant associations with delayed recall (p=4.0e-5 and 7.7e-7) and learning (p=7.6e-6 and 5.0e-8).

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nominally significantp<0.05actually significant

All 15 representative traits remained nominally significant (p<0.05) and showed consistent effect directions between marginal and conditional analyses ( Supplementary file 1 ).

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did not reach statistical significancep=0.06so close (0.05 < p ≤ 0.1)

Of note, the fluid intelligence score, one of the most significant associations identified by BADGERS, did not reach statistical significance in MR (p=0.06), which may be explained by its polygenic genetic architecture.

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