FXR-FGF19 signaling in the gut-liver axis is dysregulated in patients with cirrhosis and correlates with impaired intestinal defence.

FXR expression decreased in patients with cACLD (logfold −2.14 ± 0.46, p = 0.025) and dACLD (logfold −2.49 ± 0.35, p = 0.004), whereas SHP expression was similar in patients with cACLD ( p = 0.207) and showed a statistical trend to decrease in dACLD (logfold −1.97 ± 0.40, p = 0.107), as compared to controls.

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While there was a clear trend towards a stepwise decrease of tight junction expression between controls, cACLD, and dACLD, the subgroup comparison between cACLD and dACLD failed to reach statistical significance—which may be explained due to sample size limitations and correction for multiple testing.

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