Although these SNPs were not identified at genome-wide significance in our main analysis, we did confirm nominally significant interactions for these SNPs.
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Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer.
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The sentences
On the basis of the two-step testing, this SNP shows significant evidence of interaction with aspirin-only use; interactions were marginally significant for aspirin/NSAID use.
Similarly, no significant heterogeneity between cases with the molecular marker present versus absent was observed (all P het > 0.05), although the estimates for BRAF mutant versus wild-type and CIMP-high versus CIMP-low/negative approached significance.