Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans.

This increasing effect was also nominally significant at order and family taxonomical levels ( Desulfovibrionaceae , P = 0.003), although the significance was lost after FDR correction for multiplicity.

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The amount of the BAs per mg faeces did not change significantly after the probiotic intervention, being the 12-oxilithocholic acid the only BA metabolite with a decreasing trend at Day 28 ( P = 0.052 vs. baseline).

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A positive association was also observed at Day 28, although did not achieve significance (Rho: 0.394, P = 0.086).

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As shown in Supplementary material online , Table S11 , more than 85% of the metabolites presented a negative trend for their content in faeces after the probiotic intervention compared with baseline, but changes did not achieve statistical significance, except for glycine and sarcosine ( P = 0.014 and P = 0.025, respectively).

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