Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury.

Angpt2 protein (Figure 5 D), likewise analyzed in CtsC-KO mice using protocol I, showed a tendency towards downregulation that, however, did not reach statistical significance in the group of mice analyzed.

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Immunoblot analysis at that same time point after APAP administration showed a trend towards increased hepatic CtsC protein during intoxication ( Figure S1 C).

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