High-dose chemotherapy and autologous hematopoietic stem cell transplantation for progressive systemic sclerosis: a retrospective study of outcome and prognostic factors.

Patients reporting a subjective response after HD-ASCT had a highly significant longer OS as compared to those not reporting a subjective response ( n = 18, 75.0%; log-rank p < 0.001; Fig. 3 a).

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However, these analyses did not reach statistical significance (log-rank p ≥ 0.05).

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Female patients ( n = 20, 62.5%; log-rank p = 0.097), patients with lower CCI (< 4, n = 24, 75%; log-rank p = 0.148), BMI in normal or above-average range (≥ 18, n = 30, 93.8%; log-rank p = 0.213), and a lower mRSS (< 25, n = 11, 52.4%; log-rank p = 0.166) showed a trend to longer OS when analyzing the Kaplan–Meier curves.

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