Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice.

The absolute collagen area in the plaque was reduced (−38.3%), and a clear trend toward a lower relative collagen content of the plaque (−23%; P =0.058) was demonstrated in the ONX-0914–treated group (Figure 1 C), indicating a less progressed plaque phenotype upon ONX-0914 treatment.

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As C57BL/6J mice on a WTD are prone to develop adiposity-driven insulin resistance, 29 , 30 we assessed insulin levels in the blood, which showed a trend toward a reduction upon immunoproteasomal inhibition (Figure 5 D).

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