Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction.

3g ) of genetic associations with infarcts and with blood SMAD3 levels in ADNI and MCSA revealed 6 intronic SMAD3 variants (rs71400360, rs12904527, rs12909923, rs71400361, rs35779650, rs28564777) that had nominally significant associations ( p < 0.05) with both lower risk of brain infarcts and with higher blood levels of SMAD3 .

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There was a tendency towards increased smad3a expression in pericytes after Aβ injection, though this did not reach statistical significance (Supplementary Fig. 23C ).

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