During the intervention period, an increasing trend in VE was observed for both test products, but it did not reach superiority over placebo.
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The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial.
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The sentences
However, changes for both test groups did not reach statistical significance when compared to placebo, and no significant differences between CP and CPHA products at either T8 or T16 were observed ( p = 0.27 and 0.73, respectively). 3.5.
While both HA groups showed a trend to suppress wrinkles, the effect was significant (vs. the placebo) only for the 300 kDa group after 8 weeks; it was not significant at 12 weeks for either of the groups.