Esketamine Exposure Impairs Cardiac Development and Function in Zebrafish Larvae.

While the 1 mg/L and 100 mg/L groups showed an increasing trend but did not reach statistical significance, the gata4 transcription levels peaked in the 10 mg/L groups, showing a 1.91-fold increase over the control group ( Figure 4 B).

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Zebrafish larvae exposed to esketamine showed a trend toward higher Ach concentrations; levels rose to 1.16, 1.11, and 1.34 times that of the control group ( Figure 7 A).

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