Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with <i>APOEε4</i> and mild cognitive impairment.

All the nominally significant phosphatidylcholines in the brain show a positive association with cognitive global random slope indicating worsening with a decrease in the lipid level.

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The APOEε4 carriers in this study who are not cognitively impaired (NCI+) have a strong trend toward a higher education level overall and the age of death was not significantly different from non-carriers ( Table 1 ), suggesting that the NCI+ group may be considered resilient in this study.

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