Suspension time in the two-limb wire hang in treated 146aX mice showed an increase (39.4% increase) but did not reach statistical significance ( p = 0.163, Figure 7 A).
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Deletion of miR-146a enhances therapeutic protein restoration in model of dystrophin exon skipping.
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Fiber size distribution was also analyzed in the gastrocnemius muscles and showed a trend toward reduced fiber size variability that did not reach statistical significance ( Figures S5 E and S5E′).