Total Neoadjuvant Therapy in Localized Pancreatic Cancer: Is More Better?

Cancers (Basel) · 2024 · PMC11240662 · PMID 39001485

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.8800

boldest claim

The sentences

showed a trendp = 0.060so close (0.05 < p ≤ 0.1)

CRT significantly reduced local progression rates (32% versus 46%, p = 0.030) and showed a trend towards better median PFS (9.9 versus 8.4 months, p = 0.060) and longer median time without retreatment (6.1 versus 3.7 months, p = 0.020).

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did not reach statistical significancep = 0.88not close (p > 0.1)

For BRPC patients, the unstratified HR was 0.67 (95% CI 0.45–0.99), favoring TNT in OS, but did not reach statistical significance ( p = 0.88).

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