Il-12 expression was significantly higher in toxin-challenged controls compared to mice with tofacitinib treatment, while Ifn-γ showed a trend towards downregulation by tofacitinib.
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Tofacitinib Treatment Suppresses CD4+ T-Cell Activation and Th1 Response, Contributing to Protection against Staphylococcal Toxic Shock.
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The sentences
Similarly to what was seen in previously examined mRNA expression, the level of IL-12 was significantly lower in tofacitinib-treated animals compared to toxin-challenged controls ( Figure 4 a), while IFN-γ showed a strong trend in the same direction ( Figure 4 b).