Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer.

One additional gene, TMEM69 , which was discovered in the whole blood analyses and did not reach statistical significance in the cross-tissue discovery analyses, did not replicate in whole blood but was significantly associated with elevated PSA levels in cross-tissue replication analyses ( p = 1.948 × 10 −8 ).

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Within the whole blood gene set, analyses detected nominally significant enrichment of the renin-angiotensin-aldosterone system in KEGG, which works to regulate arterial blood pressure.

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