Late-life dietary folate restriction reduces biosynthesis without compromising healthspan in mice.

However, because of high variability in the measured values, the overall differences in P-RPS6 levels between the two dietary groups did not reach statistical significance ( Fig S13 ; P > 0.05, based on the Wilcoxon rank sum test).

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There was also a negative trend between the F/C+ diet and fat mass (slope = −1.6989, P = 0.0635), and a weaker negative association with lean mass (slope = −0.5034, P = 0.1474), although in the latter cases the effects did not reach the P < 0.05 threshold.

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