Pathway-Based Mendelian Randomization for Pre-Infection IL-6 Levels Highlights Its Role in Coronavirus Disease.

IL-6 Receptor sIL6R showed a suggestive modest negative effect on COVID-19 outcomes (ORs ranging 0.94 to 0.97) ( Figure 4 ), but these did not reach statistical significance, except for COVID-19 infection, i.e., HGI_ALL_C2 ( p = 0.0005). 3.3.

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CRP The genetically instrumented CRP showed only nominally significant associations, with ORs ranging from 1.31 to 1.60 for different COVID-19 datasets ( Figure 4 , Table S3 ).

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